PittsburghV1, Main, Exploration, bibRecord, 000517

Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.

Identifieur interne : 000517 ( Main/Exploration ); précédent : 000516; suivant : 000518

Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.

Auteurs : Berthony Deslouches [États-Unis] ; Jonathan D. Steckbeck [États-Unis] ; Jodi K. Craigo [États-Unis] ; Yohei Doi [États-Unis] ; Jane L. Burns [États-Unis] ; Ronald C. Montelaro [États-Unis]

Source :

Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2015.

RBID : pubmed:25421473

Descripteurs français

KwdFr :
- Antibactériens (pharmacologie), Bactéries (), Colistine (pharmacologie), Multirésistance bactérienne aux médicaments, Peptides antimicrobiens cationiques (pharmacologie), Rifampicine (pharmacologie), Tests de sensibilité microbienne.
MESH :
- pharmacologie : Antibactériens, Colistine, Peptides antimicrobiens cationiques, Rifampicine.
- Bactéries, Multirésistance bactérienne aux médicaments, Tests de sensibilité microbienne.

English descriptors

KwdEn :
- Anti-Bacterial Agents (pharmacology), Antimicrobial Cationic Peptides (pharmacology), Bacteria (drug effects), Colistin (pharmacology), Drug Resistance, Multiple, Bacterial, Microbial Sensitivity Tests, Rifampin (pharmacology).
MESH :
- chemical , pharmacology : Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Colistin, Rifampin.
- drug effects : Bacteria.
- Drug Resistance, Multiple, Bacterial, Microbial Sensitivity Tests.

Abstract

Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.

DOI: 10.1128/AAC.03937-14
PubMed: 25421473

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.</div>
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Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.

Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
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